1. to make hard; harden, as rock, tissue, etc.: Cold indurates the soil.
2. to make callous, stubborn, or unfeeling: transgressions that indurate the heart.
3. to inure; accustom: to indurate oneself to privation and suffering.
4. to make enduring; confirm; establish: to indurate custom through practice.
5. to become hard; harden.
6. to become established or confirmed.
http://dictionary.reference.com/browse/indurate
Years of lies had indurated the police officer's heart against stories of starving and sick children.
