-To leave abruptly.
-To abscond or Run off.
-To get out of Dodge.
From mid 19th century: blend, simulating a Latin form, of abscond, squattle ‘depart,’ and perambulate.
Used in a sentence:
"When her husband came home early, I knew it was time to absquatulate!"
(all credit for the graphic and text goes to The Grandiloquent Word of the Day FB page)