1. a medicine that relieves or allays pain.
2. anything that relieves distress or pain: The music was an anodyne to his grief.
adjective
3. relieving pain.
4. soothing to the mind or feelings.
http://dictionary.reference.com/browse/anodyne
The children's screaming was anything but an anodyne to her headache, and, in fact, it made her head hurt more.